In this research presentation, Natasha Nesic explored the psychophysiological mechanisms underlying chronic low back pain and examined evidence-based approaches to treatment. Drawing from neuroscience, pain physiology, and psychophysiological research, the work highlights how stress, autonomic nervous system activation, muscle tension, and altered pain processing contribute to the development and persistence of chronic pain. The presentation emphasizes the growing body of evidence supporting biofeedback and psychophysiological interventions as effective treatment modalities, demonstrating how targeted regulation of physiological processes can reduce pain, improve self-awareness, and enhance overall functioning. This work reflects Natasha’s broader commitment to integrating neuroscience and behavioral health to develop innovative, non-invasive approaches for complex clinical conditions.